- Research Papers On:
- Ph.D. Dissertations:
- Nuclear protein quality control
Gardner, R. G., Nelson, Z. W., and D. E. Gottschling. 2005.
Degradation-mediated protein quality control in the nucleus.
Cell 120:803-815.
Abstract
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Supplemental Material (148K)
Highlighted in a Preview in same issue.
- Chromatin regulation
Gardner, R. G., Nelson, Z. W., and D. E. Gottschling. 2005.
Ubp10/Dot4p Regulates the Persistence of Ubiquitinated Histone H2B: Distinct Roles in Telomeric Silencing and General Chromatin.
Molecular and Cellular Biology 25:6123-6139.
Abstract
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PDF (924K)
Supplemental Material (1.2M)
- ER protein quality control and sterol regulation
Gardner, R. G., Shearer, A. G., and R. Y. Hampton. 2001.
In Vivo Action of the HRD Ubiquitin Ligase Complex: Mechanisms of Endoplasmic Reticulum QualityControl and Sterol Regulation.
Molecular and Cellular Biology 21: 4276-4291.
Abstract
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Gardner, R. G., Shan, H., Matsuda, S. P. T., and R. Y. Hampton. 2001.
An oxysterol-derived positive signal for 3-hydroxy-3-methylglutaryl-CoA reductase degradation in yeast.
Journal of Biological Chemistry 276: 8681-8684.
Abstract
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Bays, N. W., Gardner, R. G., Seelig, L. P., Joazeiro, C. A., and R. Y. Hampton. 2001.
Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.
Nature Cell Biology 3:24-29.
Abstract
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Gardner, R. G., Swarbrick, G. M., Bays, N. W., Cronin, S. R., Wilhovsky, S., Seelig, L., Kim, C., and R. Y. Hampton. 2000.
Endoplasmic reticulum degradation requires lumen to cytosol signaling: transmembrane control of Hrd1p by Hrd3p.
Journal of Cell Biology 151:69-82.
Abstract
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PDF (688K)
Wilhovsky, S., Gardner, R., and R. Hampton. 2000.
HRD gene dependence of endoplasmic reticulum degradation.
Molecular Biology of the Cell 11:1697-1708.
Abstract
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PDF (428K)
Gardner, R. G. and R. Y. Hampton. 1999.
A 'distributed degron' allows regulated entry into the ER degradation pathway.
The Embo Journal 18:5994-6004.
Abstract
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Gardner, R. G. and R. Y. Hampton. 1999.
A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes.
Journal of Biological Chemistry 274:31671-31678.
Abstract
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Gardner, R., Cronin, S., Leader, B., Rine, J., and R. Hampton. 1998.
Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.
Molecular Biology of the Cell 9:2611-2626.
Abstract
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Hampton, R. Y., Gardner, R. G., and J. Rine. 1996.
Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein.
Molecular Biology of the Cell 7:2029-2044.
Abstract
PDF (2.2M)
- Ph.d. dissertations
Gardner, R. G. 2000.
A mechanistic characterization of the regulated degradation of the yeast 3-hydroxy-3-methylglutaryl coenzyme A reductase, Hmg2p.
PDF (8.9M)
