We’re generally interested in how the cell regulates protein function through post-translational modifications. Such modifications are critical to the cell because, once a protein is made, the cell must be able to control the level of activity to balance it with need.
Ubiquitin was discovered as a covalent modifier of histone H2A nearly 30 years ago, and has since emerged as one of the cell's most broadly utilized protein modifications. From a regulation perspective, ubiquitin can be thought of as a universal cellular rheostat, deployed in an array of different configurations that are used in distinct ways to regulate a myriad of activities.
We are interested in discovering new ubiquitin-related modification pathways that function in the nucleus to maintain nuclear proteostasis, control ribosome biogenesis, regulate chromatin-associated processes, or act in novel ways. To accomplish this, we're using classical genetic and biochemical techniques, as well as a variety of new high throughput methods, in yeast.
We are also interested in how the cousin of ubiquitin, the small ubiquitin-like modifier SUMO, functions during stress and allows the cell to wrestle with stress adaptation. Managing stress is a key physiological function for individual cells, organs, and organisms. Without the ability to adapt to stress through signaling mechanisms like SUMO, cells can die.
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UBIQUITIN ROCKS OUR WORLD
TOUR THE LAB
Welcome to Gardner Lab
Richard Gardner, Ph.D.
Pioneer of Gardner Lab
In 2012 Richard Gardner, founder of Gardner Lab became an Associate Professor of Pharmacology at the University of Washington...
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Ubiquitin—Nature's Cellular Garbage Collector
We're generally interested in how the cell regulates protein function through post-translational modifications. Such modifications are critical to the cell because, once a protein is made, the cell must
be able to control the level of activity to balance it with need...
READ MORE
Say Hello to Our Little Buddy: Saccharomyces Cerevisiae
Saccharomyces cerevisiae, or budding yeast, is what we use in the lab. Yeast has simple elegance, yet surprising biological complexity. Yeast has captivated generations of researchers who've used this intoxicating single-celled organism to open windows into the molecular
underpinnings of life...
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Annual Pharmacology Retreat at Islandwood
Our scientists got together and took the ferry out to Bainbridge Island.
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Check Out What's Under the Hood at UW...
Established in 2016, The Biomedical Research Hooding Ceremony celebrates the accomplishments and groundbreaking research of our students...
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A Little Help from Future Scientists Visiting the Lab
We are proud to provide opportunities to recruit curious students of all ages into biological research....
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Thank you for stopping by to learn who we are and what we do! We are located in the Department of Pharmacology at the University of Washington in Seattle. We're part of the Molecular and Cellular Biology Graduate Program, the Neurobiology and Behavior Graduate Program, the Medical Science Training Program, and the Graduate Program in the Department of Pharmacology.
Yeast is Infectious
No, not that kind of yeast. Working with baker’s or brewer’s yeast can really affect how you think about our inner body workings and how we approach science. You can pick up a package of our favorite little buddy right now at your grocery store or brewer store and work with it hands on to make bread or beer. It loves some sugar and a little bit of warmth. And with that love, you can coax so many flavors and thoughts from it.The little microbe packs so much awesome biology within its tiny package that it can be used to study science in grade school, high school, college, graduate school, and beyond. So many advances in genetics, biochemistry, and cell biology have come from what you might already have in your pantry!
MEET THE PEOPLE
At Gardner Lab, our people drive the science.
Oh. My. Science.
Here at the Gardner Lab, we love all aspects of science. From the molecular, to the genetic, to the ceullar. Post-translational modifications by ubiquitin and its variants are what we study. But that is just how we uncover the different physiological functions that interest us. We are intrigued by protein misfolding, stress-induced regulation of chromatin, and ribosome biogenesis.
READ ABOUT THE SCIENCE
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Here.
HAVE A PASSION
FOR SCIENCE?
That's what we're looking for at Gardner Lab. People who are seekers of answers, who are willing to do the work to find out how nature works. Our research has potential benefits in so many areas, and those involved have gone on to distinction in a wide variety of careers in pharmacology, cellular biology, and medical science.
CONTACT GARDNER LAB
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QUICK LINKS
A conserved deubiquitinating enzyme uses intrinsic disordered regions to scaffold multiple protein-interaction sites. JBC 290: 20601-20612.
Dynamic sumoylation of a conserved transcription corepressor prevents persistent inclusion formation during hyperosmotic stress. PLoS Genetics 12: e1005809.
Richard Gardner. The Man. The Legend...
In 2012 Richard Gardner, founder of Gardner Lab became an Associate Professor of Pharmacology at the University of Washington...
READ MORE
Ubiquitin—Nature's Cellular Garbage Collector
We're generally interested in how the cell regulates protein function through post-translational modifications. Such modifications are critical to the cell because, once a protein is made, the cell must be able to control the level of activity to balance it with need...
READ MORE
3D animation from novice to expert: After Effects CC
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Adobe Premiere Pro: Video editing like a professional
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Check Out What's Under the Hood at UW...
Donec ante diam, luctus congue turpis id, faucibus rutrum magna. Cras nisl odio, ornare quis nibh sit amet, pulvinar consectetur metus Praesent porttitor, mauris non gravida suscipit...
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A Little Help from Future Scientists Visiting the Lab
Donec ante diam, luctus congue turpis id, faucibus rutrum magna. Cras nisl odio, ornare quis nibh sit amet, pulvinar consectetur metus Praesent porttitor, mauris non gravida suscipit...
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